Stephen M. Roth, Ph.D.
Associate Professor
Exercise Physiology, Aging and Genetics
Publications
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Recent, representative publications (* indicates student advisee):
- Rankinen, T., M.S. Bray, J.M. Hagberg, L. Perusse, S.M. Roth, B. Wolfarth, C. Bouchard. The human gene map for performance and health-related fitness phenotypes: the 2005 update. Medicine and Science in Sports and Exercise, 38(11): 1863-1888, 2006.
- Prior, S.J.*, J.M. Hagberg, C. Paton, L. Douglass, M. Brown, J. McLenithan, S.M. Roth. DNA sequence variation in the promoter region of the VEGF gene impacts VEGF gene expression and maximal oxygen consumption. American Journal of Physiology Heart and Circulatory Physiology, 290: H1848-H1855, 2006
- Roth, S.M., E.J. Metter, S. Ling, L. Ferrucci. Inflammatory factors in age-related muscle wasting. Current Opinion in Rheumatology, 18(6): 625-630, 2006.
- Delmonico, M.J., M.C. Kostek, N.A. Doldo, B.D. Hand, S. Walsh*, J.M. Conway, C.R. Carignan, S.M. Roth, B.F. Hurley. Alpha-actinin-3 (ACTN3) R577X polymorphism influences knee extensor peak power response to strength training in older men and women. The Journal of Gerontology: Medical Sciences, 62A (2): 206-212, 2007.
- Walsh, S.*, E.J. Metter, L. Ferrucci, S.M. Roth. Activin RIIB and follistatin haplotype associations with muscle mass and strength in humans. Journal of Applied Physiology, 102: 2142-2148, 2007.
- Yao, L., M.J. Delmonico, S.M. Roth, B.D. Hand, J. Johns, J. Conway, L. Douglass, B.F. Hurley. Adrenergic receptor genotype influence on mid-thigh intermuscular fat response to strength training in middle-aged and older adults. The Journal of Gerontology: Medical Sciences, 62: 658-663, 2007.
- Park, J.-Y., I.K.G. Farrance, N.M Fenty, J.M. Hagberg, S.M. Roth, D.M. Mosser, M.Q. Wang, H. Jo, T. Okazaki, S.R. Brant, M.D. Brown. NFKB1 promoter variation implicates shear-induced NOS3 gene expression and endothelial function in prehypertensives and stage I hypertensives. American Journal of Physiology Heart and Circulatory Physiology, 293: H2320-H2327, 2007
- Prior, S.J.*, S.M. Roth, X. Wang, C. Kammerer, I. Miljkovic-Gacic, C.H. Bunker, V.W. Wheeler, A.L. Patrick, J.M. Zmuda. Genetic and environmental influences on skeletal muscle phenotypes as a function of age and sex in large, multi-generational families of African heritage. Journal of Applied Physiology, 103: 1121-1127, 2007. [Invited Editorial on this paper in the same issue: P.W. Franks. Muscling in on the genetics of quantitative disease traits; pages 1111-1112.]
- Hand, B.D., M.C. Kostek, R.E. Ferrell, M.J. Delmonico, L.W. Douglass, S.M. Roth, J.M. Hagberg, B.F. Hurley. Influence of promoter region variants of insulin-like growth factor pathway genes on the strength-training response of muscle phenotypes in older adults. Journal of Applied Physiology, 103: 1678-1687, 2007.
- Roth, S.M., S. Walsh*, D. Liu*, E.J. Metter, L. Ferrucci, B.F. Hurley. The ACTN3 R577X nonsense allele is under-represented in elite-level strength athletes. European Journal of Human Genetics, 16: 391-394, 2008.
- Charbonneau, D.E.*, E.D. Hanson, A.T. Ludlow*, M.J. Delmonico, B.F. Hurley, S.M. Roth. ACE genotype and the muscle hypertrophic and strength responses to strength training. Medicine and Science in Sports and Exercise, 40: 677-683, 2008.
- Roth, S.M. Functional genomics and the path to personalized medicine. Commentary article for Exercise and Sport Sciences Reviews, 36: 49-50, 2008.
- Roth, S.M. Viewpoint: Perspective on the future use of genomics in exercise prescription. Unsolicited commentary for Journal of Applied Physiology, 104: 1243-1245, 2008. [See associated invited commentaries on pages 1246-1253 in this same issue.]
- Deeny, S.P., D. Poeppel, J.B. Zimmerman, S.M. Roth, J. Brandauer, S. Witkowski, J.W. Hearn, A.T. Ludlow, J.L. Contreras-Vidal, J. Brandt, B.D. Hatfield. Exercise, APOE, and working memory: MEG and behavioral evidence for benefit of exercise in epsilon4 carriers. Biological Psychology, 78: 179-187, 2008.
- Liu, D.*, E.J. Metter, L. Ferrucci, S.M. Roth. TNF promoter polymorphisms associated with muscle phenotypes in humans. Journal of Applied Physiology, 105: 859-867, 2008.
- Roth, S.M. , S.M. Williams, L. Jiang, K.S. Menon, J.J. Jeka. Susceptibility genes for gentamicin-induced vestibular dysfunction. Journal of Vestibular Research, 18: 59-68, 2008.
- Ludlow, A.T.*, J.B. Zimmerman, S. Witkowski, J.W. Hearn, B.D. Hatfield, S.M. Roth. Relationship between physical activity, telomere length, and telomerase activity in peripheral blood mononucleocytes. Medicine and Science in Sports and Exercise, in press.
- Bray, M.S., J.M. Hagberg, L. Perusse, Rankinen, T., S.M. Roth, B. Wolfarth, C. Bouchard. The human gene map for performance and health-related fitness phenotypes: the 2006-2007 update. Medicine and Science in Sports and Exercise, in press.
- Delmonico, M.J., J.M. Zmuda, B.C. Taylor, T.B. Harris, T. Manini, A. Schwarz, R. Li, S.M. Roth, B.F. Hurley, R.E. Ferrell, A.B. Newman. Association of the ACTN3 genotype and physical functioning with aging in older adults. Journal of Gerontology Medical Sciences, in press.
- Walsh, S.*, D. Liu*, E.J. Metter, L. Ferrucci, S.M. Roth. ACTN3 genotype is associated with muscle phenotypes in women across the adult age span. Journal of Applied Physiology, in press.



