Stephen M. Roth, Ph.D.

Associate Professor

Exercise Physiology, Aging and Genetics

Publications

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Recent, representative publications (* indicates student advisee):

  1. Rankinen, T., M.S. Bray, J.M. Hagberg, L. Perusse, S.M. Roth, B. Wolfarth, C. Bouchard. The human gene map for performance and health-related fitness phenotypes: the 2005 update. Medicine and Science in Sports and Exercise, 38(11): 1863-1888, 2006.

  2. Prior, S.J.*, J.M. Hagberg, C. Paton, L. Douglass, M. Brown, J. McLenithan, S.M. Roth. DNA sequence variation in the promoter region of the VEGF gene impacts VEGF gene expression and maximal oxygen consumption. American Journal of Physiology Heart and Circulatory Physiology, 290: H1848-H1855, 2006

  3. Roth, S.M., E.J. Metter, S. Ling, L. Ferrucci. Inflammatory factors in age-related muscle wasting. Current Opinion in Rheumatology, 18(6): 625-630, 2006.

  4. Delmonico, M.J., M.C. Kostek, N.A. Doldo, B.D. Hand, S. Walsh*, J.M. Conway, C.R. Carignan, S.M. Roth, B.F. Hurley. Alpha-actinin-3 (ACTN3) R577X polymorphism influences knee extensor peak power response to strength training in older men and women. The Journal of Gerontology: Medical Sciences, 62A (2): 206-212, 2007.

  5. Walsh, S.*, E.J. Metter, L. Ferrucci, S.M. Roth. Activin RIIB and follistatin haplotype associations with muscle mass and strength in humans. Journal of Applied Physiology, 102: 2142-2148, 2007.

  6. Yao, L., M.J. Delmonico, S.M. Roth, B.D. Hand, J. Johns, J. Conway, L. Douglass, B.F. Hurley. Adrenergic receptor genotype influence on mid-thigh intermuscular fat response to strength training in middle-aged and older adults. The Journal of Gerontology: Medical Sciences, 62: 658-663, 2007.

  7. Park, J.-Y., I.K.G. Farrance, N.M Fenty, J.M. Hagberg, S.M. Roth, D.M. Mosser, M.Q. Wang, H. Jo, T. Okazaki, S.R. Brant, M.D. Brown. NFKB1 promoter variation implicates shear-induced NOS3 gene expression and endothelial function in prehypertensives and stage I hypertensives. American Journal of Physiology Heart and Circulatory Physiology, 293: H2320-H2327, 2007

  8. Prior, S.J.*, S.M. Roth, X. Wang, C. Kammerer, I. Miljkovic-Gacic, C.H. Bunker, V.W. Wheeler, A.L. Patrick, J.M. Zmuda. Genetic and environmental influences on skeletal muscle phenotypes as a function of age and sex in large, multi-generational families of African heritage. Journal of Applied Physiology, 103: 1121-1127, 2007. [Invited Editorial on this paper in the same issue:  P.W. Franks. Muscling in on the genetics of quantitative disease traits; pages 1111-1112.]

  9. Hand, B.D., M.C. Kostek, R.E. Ferrell, M.J. Delmonico, L.W. Douglass, S.M. Roth, J.M. Hagberg, B.F. Hurley. Influence of promoter region variants of insulin-like growth factor pathway genes on the strength-training response of muscle phenotypes in older adults. Journal of Applied Physiology, 103: 1678-1687, 2007.

  10. Roth, S.M., S. Walsh*, D. Liu*, E.J. Metter, L. Ferrucci, B.F. Hurley. The ACTN3 R577X nonsense allele is under-represented in elite-level strength athletes. European Journal of Human Genetics, 16: 391-394, 2008.

  11. Charbonneau, D.E.*, E.D. Hanson, A.T. Ludlow*, M.J. Delmonico, B.F. Hurley, S.M. Roth. ACE genotype and the muscle hypertrophic and strength responses to strength training. Medicine and Science in Sports and Exercise, 40: 677-683, 2008.

  12. Roth, S.M. Functional genomics and the path to personalized medicine. Commentary article for Exercise and Sport Sciences Reviews, 36: 49-50, 2008.

  13. Roth, S.M. Viewpoint: Perspective on the future use of genomics in exercise prescription. Unsolicited commentary for Journal of Applied Physiology, 104: 1243-1245, 2008. [See associated invited commentaries on pages 1246-1253 in this same issue.]

  14. Deeny, S.P., D. Poeppel, J.B. Zimmerman, S.M. Roth, J. Brandauer, S. Witkowski, J.W. Hearn, A.T. Ludlow, J.L. Contreras-Vidal, J. Brandt, B.D. Hatfield. Exercise, APOE, and working memory: MEG and behavioral evidence for benefit of exercise in epsilon4 carriers. Biological Psychology, 78: 179-187, 2008.

  15. Liu, D.*, E.J. Metter, L. Ferrucci, S.M. Roth. TNF promoter polymorphisms associated with muscle phenotypes in humans. Journal of Applied Physiology, 105: 859-867, 2008.

  16. Roth, S.M. , S.M. Williams, L. Jiang, K.S. Menon, J.J. Jeka.  Susceptibility genes for gentamicin-induced vestibular dysfunction. Journal of Vestibular Research, 18: 59-68, 2008.

  17. Ludlow, A.T.*, J.B. Zimmerman, S. Witkowski, J.W. Hearn, B.D. Hatfield, S.M. Roth. Relationship between physical activity, telomere length, and telomerase activity in peripheral blood mononucleocytes. Medicine and Science in Sports and Exercise, in press.

  18. Bray, M.S., J.M. Hagberg, L. Perusse, Rankinen, T., S.M. Roth, B. Wolfarth, C. Bouchard. The human gene map for performance and health-related fitness phenotypes: the 2006-2007 update. Medicine and Science in Sports and Exercise, in press.

  19. Delmonico, M.J., J.M. Zmuda, B.C. Taylor, T.B. Harris, T. Manini, A. Schwarz, R. Li, S.M. Roth, B.F. Hurley, R.E. Ferrell, A.B. Newman. Association of the ACTN3 genotype and physical functioning with aging in older adults. Journal of Gerontology Medical Sciences, in press.

  20. Walsh, S.*, D. Liu*, E.J. Metter, L. Ferrucci, S.M. Roth. ACTN3 genotype is associated with muscle phenotypes in women across the adult age span. Journal of Applied Physiology, in press.