Stephen M. Roth, Ph.D.
Exercise Physiology, Aging and Genetics
Dr. Roth has formal training in both exercise physiology and genetics. The work of the NIH-funded laboratory is focused on two areas: 1) Understanding the role of genetic variation (and environmental interaction) in determining inter-individual differences in skeletal muscle traits, exercise adaptations, and other health-related phenotypes. 2) Exploring the role of physical activity in altering DNA structure, including investigations of both telomere length and epigenetics (e.g., DNA methylation).
Recent student-led projects include analysis of the association of physical activity levels with telomere length and telomerase enzyme activity; molecular analysis of the impact of genetic variation in the androgen receptor gene on muscle gene regulation; investigation of the role of physical activity ancestry in body composition, metabolism, and gene expression in mice.
The Functional Genomics Lab also collaborates with other groups on a variety of genetics-related projects, including studies of hypertension and exercise responses, and exercise as a moderator of genetic risk of dementia.